Very High Levels Of 'Good' Cholesterol May Live On Harmful
Sunday, December 31, 2017
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Very high levels of high-density lipoprotein (HDL or "good") cholesterol may last associated alongside an increased peril of meat railroad train on too death, according to question presented today at ESC Congress 2018.1
Study writer Dr Marc Allard-Ratick, of Emory University School of Medicine, Atlanta, US, said: "It may last fourth dimension to alter the manner nosotros persuasion HDL cholesterol. Traditionally, physicians receive got told their patients that the higher your 'good' cholesterol, the better. However, the results from this study too others advise that this may no longer last the case."
HDL cholesterol has been considered "good" because the HDL molecule is involved inward the carry of cholesterol from the blood too blood vessel walls to the liver too ultimately out of the body, thereby reducing the peril of clogged arteries too atherosclerosis. People alongside depression HDL cholesterol receive got a greater peril of atherosclerosis too cardiovascular disease. But the protective lawsuit of real high HDL cholesterol has been unclear.
This study, conducted equally constituent of the Emory Cardiovascular Biobank, investigated the human relationship betwixt HDL cholesterol levels too the peril of meat railroad train on too decease inward 5,965 individuals, to a greater extent than or less of whom had meat disease. The average historic menstruum of participants was 63 years too 35% were female.
Participants were divided into v groups according to their HDL cholesterol level: less than thirty mg/dl (0.78 mmol/L), 31-40 mg/dl (0.8-1 mmol/L); 41-50 mg/dl (1.1-1.3 mmol/L); 51-60 mg/dl (1.3-1.5 mmol/L); too greater than lx mg/dl (1.5 mmol/L).
During a median follow-up of 4 years, 769 (13%) participants had a meat railroad train on or died from a cardiovascular cause. Participants alongside HDL cholesterol 41-60 mg/dl (1.1-1.5 mmol/L) had the lowest peril of meat railroad train on or cardiovascular death. Risk was increased both inward participants alongside depression levels (less than 41 mg/dl) too real high levels (greater than lx mg/dl) of HDL cholesterol, which produced a U-shaped bend when plotted graphically.
Participants alongside HDL cholesterol levels greater than lx mg/dl (1.5 mmol/L) had a nearly 50% increased peril of dying from a cardiovascular displace or having a meat railroad train on compared to those alongside HDL cholesterol levels 41-60 mg/dl (1.1-1.5 mmol/L).
The associations were consistent fifty-fifty later on controlling for other peril factors for meat affliction such equally diabetes, smoking, too low-density lipoprotein (LDL or "bad") cholesterol, likewise equally other factors linked alongside high HDL cholesterol such equally alcohol intake, race, too sex.
The results back upwards findings from several large population-based studies, including a recent publication which found increased cardiovascular too all-cause decease when HDL cholesterol reached extremely high levels.2 Dr Allard-Ratick said: "Our results are of import because they contribute to a steadily growing trunk of show that real high HDL cholesterol levels may non last protective, too because dissimilar much of the other information available at this time, this study was conducted primarily inward patients alongside established meat disease."
He noted that to a greater extent than question is needed to elucidate the mechanisms of this paradoxical association. "While the respond remains unknown, i possible explanation is that extremely elevated HDL cholesterol may stand upwards for 'dysfunctional HDL' which may promote rather than protect against cardiovascular disease," he said.
Dr Allard-Ratick concluded: "One matter is certain: the mantra of HDL cholesterol equally the 'good' cholesterol may no longer last the example for everyone."
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Study writer Dr Marc Allard-Ratick, of Emory University School of Medicine, Atlanta, US, said: "It may last fourth dimension to alter the manner nosotros persuasion HDL cholesterol. Traditionally, physicians receive got told their patients that the higher your 'good' cholesterol, the better. However, the results from this study too others advise that this may no longer last the case."
HDL cholesterol has been considered "good" because the HDL molecule is involved inward the carry of cholesterol from the blood too blood vessel walls to the liver too ultimately out of the body, thereby reducing the peril of clogged arteries too atherosclerosis. People alongside depression HDL cholesterol receive got a greater peril of atherosclerosis too cardiovascular disease. But the protective lawsuit of real high HDL cholesterol has been unclear.
This study, conducted equally constituent of the Emory Cardiovascular Biobank, investigated the human relationship betwixt HDL cholesterol levels too the peril of meat railroad train on too decease inward 5,965 individuals, to a greater extent than or less of whom had meat disease. The average historic menstruum of participants was 63 years too 35% were female.
Participants were divided into v groups according to their HDL cholesterol level: less than thirty mg/dl (0.78 mmol/L), 31-40 mg/dl (0.8-1 mmol/L); 41-50 mg/dl (1.1-1.3 mmol/L); 51-60 mg/dl (1.3-1.5 mmol/L); too greater than lx mg/dl (1.5 mmol/L).
During a median follow-up of 4 years, 769 (13%) participants had a meat railroad train on or died from a cardiovascular cause. Participants alongside HDL cholesterol 41-60 mg/dl (1.1-1.5 mmol/L) had the lowest peril of meat railroad train on or cardiovascular death. Risk was increased both inward participants alongside depression levels (less than 41 mg/dl) too real high levels (greater than lx mg/dl) of HDL cholesterol, which produced a U-shaped bend when plotted graphically.
Participants alongside HDL cholesterol levels greater than lx mg/dl (1.5 mmol/L) had a nearly 50% increased peril of dying from a cardiovascular displace or having a meat railroad train on compared to those alongside HDL cholesterol levels 41-60 mg/dl (1.1-1.5 mmol/L).
The associations were consistent fifty-fifty later on controlling for other peril factors for meat affliction such equally diabetes, smoking, too low-density lipoprotein (LDL or "bad") cholesterol, likewise equally other factors linked alongside high HDL cholesterol such equally alcohol intake, race, too sex.
The results back upwards findings from several large population-based studies, including a recent publication which found increased cardiovascular too all-cause decease when HDL cholesterol reached extremely high levels.2 Dr Allard-Ratick said: "Our results are of import because they contribute to a steadily growing trunk of show that real high HDL cholesterol levels may non last protective, too because dissimilar much of the other information available at this time, this study was conducted primarily inward patients alongside established meat disease."
He noted that to a greater extent than question is needed to elucidate the mechanisms of this paradoxical association. "While the respond remains unknown, i possible explanation is that extremely elevated HDL cholesterol may stand upwards for 'dysfunctional HDL' which may promote rather than protect against cardiovascular disease," he said.
Dr Allard-Ratick concluded: "One matter is certain: the mantra of HDL cholesterol equally the 'good' cholesterol may no longer last the example for everyone."