Statin Role Reduces Mortality As Well As Stroke Risk Inwards Dementia Patients
Thursday, January 31, 2019
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Credit: European Academy of Neurology (EAN)
(Oslo, Monday, 01 July, 2019) The usage of statins is significantly associated amongst a reduction inwards the take away a opportunity of mortality inwards dementia patients, novel question presented today at the 5th European Academy of Neurology (EAN) Congress has shown.
The study, which analysed 44,920 Swedish dementia patients from the Swedish Dementia Registry betwixt 2008-2015, flora users of statins had a 22% lower take away a opportunity of all-cause expiry compared to matched non-users.
The question also demonstrated that statin users had a 23% reduction inwards the take away a opportunity of stroke, which is 3 times to a greater extent than probable inwards patients amongst mild dementia together with 7 times to a greater extent than probable inwards those amongst severe dementia.
The protective lawsuit of statins on survival were rigid for patients younger than 75 years (27% reduction) together with inwards men (26% reduction) precisely women together with older patients also benefited (17% together with 20% reduction respectively). Patients amongst vascular dementia - the instant nigh mutual type of dementia afterward Alzheimer's illness - also saw a 29% lower mortality risk.
"Survival inwards patients inwards dementia is variable, together with previous studies select identified many factors associated amongst survival together with take away a opportunity of stroke inwards these patients", commented start writer Bojana Petek, MD, from the University Medical Center Ljubljana, Slovenia together with the Karolinska Institutet, Sweden. "However, the lawsuit of statins on these ii outcomes is non clear. The aim of this study was to analyse the association betwixt the usage of statins on the take away a opportunity of expiry together with stroke inwards patients diagnosed amongst dementia."
Commenting on their research, atomic number 82 writer Dr Sara Garcia-Ptacek from the Karolinska Institutet, Sweden, stated, "This is a cohort study, which way patients were non randomized to a handling similar they would last inwards a clinical trial. For this reason, nosotros tin forcefulness out alone demonstrate an association, together with non definitely evidence that statins caused this spend upward inwards mortality. However, our results are encouraging together with propose that patients amongst dementia do goodness from statins to a similar extent than patients without dementia."
Affecting approximately 10 i 1000 one thousand people inwards Europe, dementia is the leading travail of dependency together with disability amidst older people across the continent. The issue of cases is expected to double yesteryear 2030, largely due to the ageing population. The prevalence of dementia increases exponentially amongst age, affecting 5% of the population over 65, together with upward to 50% yesteryear ninety years of age.
For farther data or to verbalize to an expert, delight contact Luke Paskins or Hannah Murray at press@ean.org or telephone cry upward +44 (0) 1444 811099.
About the Expert:
Bojana Petek, MD, is from Division of Neurogeriatrics, Department of Neurobiology, Care Sciences together with Society, Karolinska Institutet, Stockholm, Sweden together with the Department of Neurology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Dr. Sara Garcia-Ptacek, the Senior Author, is from the Department of Neurobiology, Care Sciences together with Society, Karolinska Institutet, Sweden.
EAN - The Home of Neurology:
The European Academy of Neurology (EAN) is Europe's habitation of neurology. Founded inwards 2014, through the merger of ii European neurological societies, EAN represents the interests of to a greater extent than than 45,000 private members together with 47 national institutional members from across the continent. This year, EAN celebrates its 5th twelvemonth of fostering excellence inwards European neurology together with volition convey together to a greater extent than than 6,000 neurologists together with related scientists to the biggest full general neurology conference inwards Europe.
In Oslo, Norway, from June 29 to July 2, in that place volition last an telephone commutation of cognition together with advertisement of best practice, amongst a focus on the chief theme of neuroinflammation. The EAN Congress volition also comprehend all neurological diseases together with disorders, including the large 7: epilepsy, stroke, headache, multiple sclerosis, dementia, motion disorders, neuromuscular disorders.
References:
1. Statins, take away a opportunity of expiry together with stroke inwards patients amongst dementia - a registry-based study. Petek B, Villa-Lopez M, Winblad B, Kramberger MG, von Euler M, Xu H, Eriksdotter M, Garcia-Ptacek S, presented at the 5th Congress of International Neurology inwards Oslo.
2. The Swedish Dementia Registry (SveDem): http://www.
3. Journal of Internal Medicine. 2017. Management of acuate ischaemic stroke inwards patients amongst dementia. Available at: https:/
4. WHO Europe, Dementia. Available at: http://www.
The study, which analysed 44,920 Swedish dementia patients from the Swedish Dementia Registry betwixt 2008-2015, flora users of statins had a 22% lower take away a opportunity of all-cause expiry compared to matched non-users.
The question also demonstrated that statin users had a 23% reduction inwards the take away a opportunity of stroke, which is 3 times to a greater extent than probable inwards patients amongst mild dementia together with 7 times to a greater extent than probable inwards those amongst severe dementia.
The protective lawsuit of statins on survival were rigid for patients younger than 75 years (27% reduction) together with inwards men (26% reduction) precisely women together with older patients also benefited (17% together with 20% reduction respectively). Patients amongst vascular dementia - the instant nigh mutual type of dementia afterward Alzheimer's illness - also saw a 29% lower mortality risk.
"Survival inwards patients inwards dementia is variable, together with previous studies select identified many factors associated amongst survival together with take away a opportunity of stroke inwards these patients", commented start writer Bojana Petek, MD, from the University Medical Center Ljubljana, Slovenia together with the Karolinska Institutet, Sweden. "However, the lawsuit of statins on these ii outcomes is non clear. The aim of this study was to analyse the association betwixt the usage of statins on the take away a opportunity of expiry together with stroke inwards patients diagnosed amongst dementia."
Commenting on their research, atomic number 82 writer Dr Sara Garcia-Ptacek from the Karolinska Institutet, Sweden, stated, "This is a cohort study, which way patients were non randomized to a handling similar they would last inwards a clinical trial. For this reason, nosotros tin forcefulness out alone demonstrate an association, together with non definitely evidence that statins caused this spend upward inwards mortality. However, our results are encouraging together with propose that patients amongst dementia do goodness from statins to a similar extent than patients without dementia."
Affecting approximately 10 i 1000 one thousand people inwards Europe, dementia is the leading travail of dependency together with disability amidst older people across the continent. The issue of cases is expected to double yesteryear 2030, largely due to the ageing population. The prevalence of dementia increases exponentially amongst age, affecting 5% of the population over 65, together with upward to 50% yesteryear ninety years of age.
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Notes to Editors: Press Enquiries: For farther data or to verbalize to an expert, delight contact Luke Paskins or Hannah Murray at press@ean.org or telephone cry upward +44 (0) 1444 811099.
About the Expert:
Bojana Petek, MD, is from Division of Neurogeriatrics, Department of Neurobiology, Care Sciences together with Society, Karolinska Institutet, Stockholm, Sweden together with the Department of Neurology, University Medical Center Ljubljana, Ljubljana, Slovenia.
Dr. Sara Garcia-Ptacek, the Senior Author, is from the Department of Neurobiology, Care Sciences together with Society, Karolinska Institutet, Sweden.
EAN - The Home of Neurology:
The European Academy of Neurology (EAN) is Europe's habitation of neurology. Founded inwards 2014, through the merger of ii European neurological societies, EAN represents the interests of to a greater extent than than 45,000 private members together with 47 national institutional members from across the continent. This year, EAN celebrates its 5th twelvemonth of fostering excellence inwards European neurology together with volition convey together to a greater extent than than 6,000 neurologists together with related scientists to the biggest full general neurology conference inwards Europe.
In Oslo, Norway, from June 29 to July 2, in that place volition last an telephone commutation of cognition together with advertisement of best practice, amongst a focus on the chief theme of neuroinflammation. The EAN Congress volition also comprehend all neurological diseases together with disorders, including the large 7: epilepsy, stroke, headache, multiple sclerosis, dementia, motion disorders, neuromuscular disorders.
References:
1. Statins, take away a opportunity of expiry together with stroke inwards patients amongst dementia - a registry-based study. Petek B, Villa-Lopez M, Winblad B, Kramberger MG, von Euler M, Xu H, Eriksdotter M, Garcia-Ptacek S, presented at the 5th Congress of International Neurology inwards Oslo.
2. The Swedish Dementia Registry (SveDem): http://www.
3. Journal of Internal Medicine. 2017. Management of acuate ischaemic stroke inwards patients amongst dementia. Available at: https:/
4. WHO Europe, Dementia. Available at: http://www.