Oral Micronized Progesterone May Decrease Perimenopausal Hot Flashes, Nighttime Sweats
Sunday, July 6, 2014
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Oral micronized progesterone (OMP) may diminish hot flashes in addition to nighttime sweats inward perimenopausal women, novel query from Canada reports. The results volition hold out presented on Monday, March xix at ENDO 2018, the 100th annual coming together of the Endocrine Society inward Chicago, Ill.
"Almost a quarter of all women today are inward perimenopause. They are oft working likewise equally maintaining a dwelling in addition to caring for children in addition to elders. About xx per centum of them volition ask effective handling for hot flashes in addition to nighttime sweats to maintain to hold out productive," said Pb writer Jerilynn C. Prior, M.D., a professor inward the Department of Medicine of the Division of Endocrinology in addition to Metabolism at the University of British Columbia, inward Vancouver, Canada.
"Hot flashes in addition to nighttime sweats travel on inward viii of 10 perimenopausal women (who've had a menses inward the final year)," Prior said. "At present, in that location is no effective therapy for them. Although non scientifically proven to hold out effective, women are oft prescribed the nascency command pill for hot flash symptoms, which may non hold out prophylactic because women's risks for blood clots in addition to strokes increment amongst historic menses in addition to weight gain."
The researchers studied OMP taken every nighttime at bedtime to process perimenopausal vasomotor symptoms (VMS), for iii reasons, Prior said: Progesterone is effective for menopausal hot flashes in addition to nighttime sweats; progesterone levels are lower than normal inward perimenopause; in addition to progesterone increases deep slumber in addition to doesn't crusade blood clots.
Prior in addition to her colleagues randomized 189 women throughout Canada: Over iii months, 93 received OMP 300 mg at bedtime in addition to 96 received placebo. Both groups were similar at baseline, in addition to overall, two-thirds of the women had skipped a menses in addition to nigh all (98 percent) were existence awakened twice a calendar week amongst nighttime sweats.
Self-reported perceived decreases inward daytime in addition to nighttime VMS intensity in addition to inward nighttime sweats were significantly greater amid the women taking OMP than amid those on placebo.
By calendar month three, hot flashes in addition to nighttime sweats had decreased inward the women inward the progesterone group. Although that decrease was non statistically dissimilar from placebo, the women taking progesterone experienced a clinically of import difference: they perceived that their hot flashes were significantly less intense in addition to that their nighttime sweats were significantly improved, compared amongst placebo.
Overall, 93 per centum of the women completed the study, in addition to the women were rattling probable to direct hold their study medication (91.4 per centum of those on progesterone in addition to 84.4 per centum of those on placebo). No increased serious or drug-related side effects were reported.
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