Vitamin D Powerfulness Last Telephone Substitution To Syndrome Affecting One-Half Of Women Aged L Or Addition
Tuesday, July 1, 2014
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Results of a study carried out inward Brazil showed a rigid association betwixt vitamin D deficiency in addition to metabolic syndrome inward postmenopausal women. The Metabolic syndrome (MetS), described every bit a cluster of atmospheric condition that enhance the remove chances of middle disease, stroke in addition to diabetes, is estimated to impact some 50% of the woman individual population to a higher house the historic period of time of 50 inward the United States.
Researchers at São Paulo State University's Botucatu Medical School (FMB-UNESP) detected MetS inward 57.8% of the women analyzed amongst vitamin D insufficiency (20-29 nanograms per milliliter of blood) or deficiency (less than twenty ng/ml) in addition to inward alone 39.8% of participants amongst sufficient vitamin D (30 ng/ml or more).
MetS is estimated to impact some 50% of the woman individual population to a higher house the historic period of time of 50 inward the United States.
The results of the study, which was supported past times the São Paulo Research Foundation - FAPESP, were published inward the magazine Maturitas.
The study population consisted of 463 women aged betwixt 45 in addition to 75. They were monitored for 2 years at FMB-UNESP's Climacteric & Menopause Outpatient Clinic. Their concluding menstruum occurred at to the lowest degree 12 months previously, in addition to they had no existing or pre-existing middle problems.
To signal whether or non the patient had MetS, the study adopted the typical parameters for MetS diagnosis: waist circumference to a higher house 88 cm, high blood pressure level (above 130/85 mmHg), high blood carbohydrate (fasting glucose to a higher house 100 mg/dL), in addition to abnormal levels of triglycerides (above 150 mg/dL) in addition to cholesterol (HDL below 50 mg/dL). MetS was diagnosed if 3 or to a greater extent than of these criteria were met.
"We measured the participants' blood vitamin D levels in addition to also analyzed parameters indicating MetS. We establish that the lower the flat of blood vitamin D, the greater the occurrence of MetS. The results suggest that supplementing in addition to maintaining adequate levels of vitamin D inward postmenopausal women tin trim down the remove chances of disease," said Eliana Aguiar Petri Nahas, a professor inward FMB-UNESP's Department of Gynecology & Obstetrics in addition to 1 of the authors of the study.
Previous studies described the beingness of several mechanisms that mightiness explicate the lawsuit of vitamin D on the components of MetS. According to the article, the near plausible explanation for the association is that vitamin D influences insulin secretion in addition to sensitivity, which play a major purpose inward MetS.
"The vitamin D receptor is expressed inward insulin-secreting pancreatic beta cells in addition to inward peripheral target tissues such every bit skeletal musculus in addition to adipose tissue. Vitamin D deficiency tin compromise the capacity of beta cells to convert pro-insulin to insulin," wrote the researchers of the FAPESP-funded project.
According to the researchers, however, to a greater extent than studies are needed to confirm the link. "The objective of the study was to evaluate the association betwixt vitamin D deficiency in addition to remove chances factors for MetS inward postmenopausal women," they write inward the article.
Extra-osseous effects
In a previous study, the UNESP researchers also analyzed the association betwixt vitamin D deficiency in addition to pectus cancer inward postmenopausal women. The survey involved 192 women aged 45-75 amongst a recent diagnosis of pectus cancer in addition to inward amenorrhea for over 12 months.
Levels of vitamin D were sufficient inward 33.9% of the patients in addition to insufficient or deficient inward 66.1%. H5N1 higher proportion of those amongst vitamin D insufficiency or deficiency had high-grade tumors or metastatic disease.
The researchers on this squad are advancing the agreement of the effects of vitamin D on chronic diseases such every bit obesity, hypertension, diabetes, in addition to consequently MetS, every bit good every bit pectus cancer.
"The importance of vitamin D to os majority is good understood, peculiarly inward helping absorb calcium into the bones," Nahas said. "Now, we're studying the extra-osseous effects of vitamin D on the cardiovascular organization in addition to on the breasts. These are the focus for our electrical flow study. In recent years, associations accept been proposed betwixt vitamin D deficiency in addition to both inflammation in addition to cardiometabolic diseases. However, to a greater extent than data is needed on the link betwixt vitamin D in addition to cardioinflammatory markers inward the full general population."
According to Nahas, aging is a commutation factor inward vitamin D deficiency. "Exposure to the Sun activates a form of pre-vitamin D inward the adipose tissue nether the skin," she explained. "Aging leads non merely to loss of musculus majority but also to changes inward trunk composition, in addition to this pre-vitamin D is lost. That's why older people create less vitamin D fifty-fifty if they run enough of sunlight."
Forthcoming query planned past times the grouping volition focus on isolated vitamin D supplementation in addition to indicators of cardiovascular illness inward postmenopausal women.
"More studies are required inward lodge to brand these of import associations inward damage of the effects of supplementation on cardiometabolic syndrome, the immune in addition to inflammatory mechanisms of cardiovascular illness inward postmenopausal women, in addition to their character of life," Nahas said.
In her view, postmenopausal women deserve in addition to require to a greater extent than specific care. They should essay medical advice on the remove for vitamin D supplementation. "Hypovitaminosis tin accept repercussions, live on it on pectus cancer, vascular illness or metabolic syndrome," she said.