Association Betwixt Migraine Diagnoses Together With All-Cause Dementia Together With Alzheimer's Affliction Was Entirely Pregnant Inwards Women
Thursday, August 22, 2019
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Several studies accept lately focused on the association betwixt migraine headaches as well as other headaches as well as dementia as well as institute a positive migraine-dementia relationship. However, almost of these studies accept failed to simultaneously accommodate for several mutual comorbidities, thence potentially introducing bias into their findings.
The finish of the introduce study, which volition live published inward the adjacent number of the Journal of Alzheimer's Disease, was to investigate the association betwixt migraine diagnoses as well as dementia inward patients followed inward full general practices inward the United Kingdom.
This study was based on information from the Disease Analyzer database (IQVIA), which compiles drug prescriptions, diagnoses, as well as basic medical as well as demographic information obtained straight as well as inward anonymous format from figurer systems used inward the practices of full general practitioners as well as specialists.
The electrical flow study sample included patients who had received a migraine diagnosis inward i of 67 full general practices inward the Great Britain betwixt Jan 1997 as well as Dec 2016 (index date). Inclusion criteria were every bit follows: an observation fourth dimension of at to the lowest degree 12 months prior to the index date; a follow-up fourth dimension of at to the lowest degree 12 months later the index date; aged betwixt threescore as well as lxxx years at the index date; as well as no diagnosis of dementia or mild cognitive damage prior to or at the index date. After applying like inclusion criteria, patients without migraine diagnoses were matched 1:1 to patients alongside migraine diagnoses based on propensity scores using a greedy algorithm as well as derived from the logistic regression using age, sex, index year, as well as co-diagnoses (i.e. diabetes mellitus, hyperlipidemia, coronary pump disease, stroke including transient ischemic attack, depression, intracranial injury, mental as well as behavioral disorders due to alcohol use, epilepsy, Parkinson's disease, osteoporosis). The index appointment for participants without migraine diagnoses was a randomly selected watch betwixt Jan 1997 as well as Dec 2016. The principal consequence of the study was the incidence of dementia every bit a business office of migraine diagnosis inside 10 years of the index date.
The introduce study included 3,727 individuals alongside as well as 3,727 individuals without a migraine diagnosis. Mean historic menstruation was 67.7 years as well as 72.9% of patients were women. Within 10 years of the index date, 5.2% of the participants alongside as well as 3.7% of the participants without migraine diagnoses were diagnosed alongside dementia (p-value<0 .001="" 3.4="" 3.6="" 4.5="" 5.8="" and="" figures="" in="" men="" p-value="0.722)." p="" respective="" the="" were="" women=""> However, a positive association betwixt migraine diagnoses as well as all-cause dementia as well as Alzheimer's illness was solely pregnant inward women (Hazard Ratio (HR): 1.65; Alzheimer's disease: HR=2.27), non inward men.
"Several biological as well as clinical hypotheses may explicate the association betwixt migraine headaches as well as dementia," explained Dr. Louis Jacob, PhD, from the University of Versailles Saint-Quentin-en-Yvelines. "For example, migraine headaches postulate chronic pain, which has been institute to substantially impact the peril of retentiveness reject as well as dementia. As women normally accept to a greater extent than severe migraine attacks, the peril of dementia inward women alongside migraine could live higher than inward men alongside migraine."
"We accept conducted several studies focused on dementia inward recent years," noted corresponding writer Prof. Karel Kostev, PhD, from the Epidemiology Department of IQVIA (Germany). "We accept been able to pose positive associations betwixt osteoporosis as well as dementia as well as betwixt epilepsy as well as dementia, but accept also observed the negative association betwixt about antiepileptic, antidepressant, as well as antihypertensive drugs as well as dementia incidence. Such findings demonstrate the pregnant usage of anonymous patient information inward epidemiology inquiry for helping people recognize as well as avoid wellness peril factors inward the future."
The authors of the study also noted that "further studies are warranted to gain a ameliorate agreement of the underlying mechanisms of the migraine-dementia human relationship as well as the unlike sexes inward the association betwixt migraine as well as dementia."
The iii major strengths of this study are the large number of patients available for analysis, the usage of real-world information including several comorbidities, as well as the matched-pair design.
However, this study also has 2 major limitations. Although the prevalence of migraine headaches is the highest inward immature adults as well as tends to decrease alongside age, this study solely included participants aged betwixt threescore as well as lxxx years, thence potentially introducing a bias into the statistical analyses. Furthermore, headaches related to an underlying ischemic cerebral lesion are ofttimes misdiagnosed every bit migraine headaches inward the elderly, which may accept affected the results of the introduce study.
This study was based on information from the Disease Analyzer database (IQVIA), which compiles drug prescriptions, diagnoses, as well as basic medical as well as demographic information obtained straight as well as inward anonymous format from figurer systems used inward the practices of full general practitioners as well as specialists.
The electrical flow study sample included patients who had received a migraine diagnosis inward i of 67 full general practices inward the Great Britain betwixt Jan 1997 as well as Dec 2016 (index date). Inclusion criteria were every bit follows: an observation fourth dimension of at to the lowest degree 12 months prior to the index date; a follow-up fourth dimension of at to the lowest degree 12 months later the index date; aged betwixt threescore as well as lxxx years at the index date; as well as no diagnosis of dementia or mild cognitive damage prior to or at the index date. After applying like inclusion criteria, patients without migraine diagnoses were matched 1:1 to patients alongside migraine diagnoses based on propensity scores using a greedy algorithm as well as derived from the logistic regression using age, sex, index year, as well as co-diagnoses (i.e. diabetes mellitus, hyperlipidemia, coronary pump disease, stroke including transient ischemic attack, depression, intracranial injury, mental as well as behavioral disorders due to alcohol use, epilepsy, Parkinson's disease, osteoporosis). The index appointment for participants without migraine diagnoses was a randomly selected watch betwixt Jan 1997 as well as Dec 2016. The principal consequence of the study was the incidence of dementia every bit a business office of migraine diagnosis inside 10 years of the index date.
The introduce study included 3,727 individuals alongside as well as 3,727 individuals without a migraine diagnosis. Mean historic menstruation was 67.7 years as well as 72.9% of patients were women. Within 10 years of the index date, 5.2% of the participants alongside as well as 3.7% of the participants without migraine diagnoses were diagnosed alongside dementia (p-value<0 .001="" 3.4="" 3.6="" 4.5="" 5.8="" and="" figures="" in="" men="" p-value="0.722)." p="" respective="" the="" were="" women=""> However, a positive association betwixt migraine diagnoses as well as all-cause dementia as well as Alzheimer's illness was solely pregnant inward women (Hazard Ratio (HR): 1.65; Alzheimer's disease: HR=2.27), non inward men.
"Several biological as well as clinical hypotheses may explicate the association betwixt migraine headaches as well as dementia," explained Dr. Louis Jacob, PhD, from the University of Versailles Saint-Quentin-en-Yvelines. "For example, migraine headaches postulate chronic pain, which has been institute to substantially impact the peril of retentiveness reject as well as dementia. As women normally accept to a greater extent than severe migraine attacks, the peril of dementia inward women alongside migraine could live higher than inward men alongside migraine."
"We accept conducted several studies focused on dementia inward recent years," noted corresponding writer Prof. Karel Kostev, PhD, from the Epidemiology Department of IQVIA (Germany). "We accept been able to pose positive associations betwixt osteoporosis as well as dementia as well as betwixt epilepsy as well as dementia, but accept also observed the negative association betwixt about antiepileptic, antidepressant, as well as antihypertensive drugs as well as dementia incidence. Such findings demonstrate the pregnant usage of anonymous patient information inward epidemiology inquiry for helping people recognize as well as avoid wellness peril factors inward the future."
The authors of the study also noted that "further studies are warranted to gain a ameliorate agreement of the underlying mechanisms of the migraine-dementia human relationship as well as the unlike sexes inward the association betwixt migraine as well as dementia."
The iii major strengths of this study are the large number of patients available for analysis, the usage of real-world information including several comorbidities, as well as the matched-pair design.
However, this study also has 2 major limitations. Although the prevalence of migraine headaches is the highest inward immature adults as well as tends to decrease alongside age, this study solely included participants aged betwixt threescore as well as lxxx years, thence potentially introducing a bias into the statistical analyses. Furthermore, headaches related to an underlying ischemic cerebral lesion are ofttimes misdiagnosed every bit migraine headaches inward the elderly, which may accept affected the results of the introduce study.
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