Among Older Women, The Naturally Occurring Hormone Dhea May Save Os Together With Musculus Majority

Women 55 together with older accept an increased jeopardy of os together with musculus loss precisely therapy amongst the hormone Dehydroepiandrosterone (DHEA) may assist foreclose os loss together with increment musculus majority inwards older women, according to a novel study led past times Catherine M. Jankowski, PhD, FACSM, an practise physiologist together with associate professor at the University of Colorado College of Nursing at the Anschutz Medical Campus. The study was published final calendar month inwards the mag Clinical Endocrinology together with highlighted inwards Endocrinology Today.
Jankowski together with colleagues analyzed information from 4 single-site, double-blinded, placebo-controlled, randomized clinical trials sponsored past times the National Institute on Aging designed to assess the effects of oral DHEA therapy on os mineral density (BMD) together with torso composition inwards women together with men betwixt the ages of 55 to 85 who were non using sexual practice hormone therapy.
The dose of DHEA used inwards the studies increased circulating DHEA sulfate levels to that of immature adults.
"Because age-related decreases inwards androgen together with estrogen production contribute to the loss of os together with musculus majority inwards older adults, restoring DHEAS to youthful levels may hold upward an effective strategy for maintaining os together with muscle," said Jankowski.
In all 4 studies, dual-energy X-ray absorptiometry (DXA) was used to stair out full torso fatty together with thin (muscle) mass, together with os mineral density of the proximal femur, full hip, together with lumbar spine at baseline together with afterwards 12 months of DHEA or placebo administration. Serum DHEA sulfate, estradiol, testosterone, sexual practice hormone-binding globulin together with insulin-like growth constituent I concentrations were besides measured at baseline together with at 12 months. Researchers merged information from the 4 studies into a fundamental database together with compared the 12-month changes inwards BMD, torso composition, circulating hormones, together with growth factors inwards answer to oral DHEA therapy versus placebo.
Of the 486 cases, 138 women together with 98 men had depression os mass, together with 29 women together with xi men had osteoporosis. The researchers establish that DHEA therapy was associated amongst increased BMD of the lumbar spine, full hip together with trochanter inwards women, precisely non inwards men. The increases inwards BMD inwards women were non every bit large every bit seen amongst other treatments such every bit bisphosphonates.
"Unlike about pharmaceutical trials targeting BMD, the DHEA trials nosotros conducted did non target women amongst osteoporosis, which may accept contributed to the little increases inwards BMD," said the researchers.
"It is possible that DHEA therapy could hold upward a strategy to mitigate the turn down inwards BMD inwards postmenopausal women who produce non tolerate other treatments," according to Jankowski. However, the authors besides concluded that the security of long-term DHEA therapy (more than i year) needs farther research.
The investigators besides establish sex-specific results effects on fat-free majority (which includes musculus mass) inwards women together with a decrease of 0.4 kg fatty majority inwards men. None of the 4 trials controlled for practise behaviors, which could accept contributed to the increment inwards fat-mass of women taking DHEA.
"Combining DHEA therapy amongst resistance practise that imparts mechanical strain to os may promote greater increases inwards musculus majority together with BMD compared to either intervention alone," stated Jankowski. "The beneficial effects of DHEA replacement on torso composition are to modestly increment fat-free majority inwards women together with decrease fatty majority inwards older men, a reversal of the green age-related trends inwards musculus together with fat." Jankowski together with colleagues are currently conducting a randomized placebo-controlled trial to create upward one's heed the independent together with combined effects of bone-loading practise together with DHEA on BMD together with musculus majority inwards postmenopausal women amongst depression os majority or moderate osteoporosis (NCT# 03227458).
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